Cook ground turkey in a large skillet or pot over medium high heat until it starts to brown. Add in the onion and garlic and continue cooked through and onions have softened. Add in the taco seasoning mix and diced tomatoes and cook for an additional minute.
Pour the water and milk into the skillet. Bring to a low boil and add in the dried macaroni and cook, uncovered, until al dente (about 6-8 minutes). Turn off heat and stir in the cheddar cheese and cream cheese until combined. Allow mixture to sit for a minute or two to thicken before serving.
Taco pasta is a quick and easy one pot dinner that can be served immediately or made ahead and reheated over low heat.